diff --git a/pw_presubmit/py/pw_presubmit/format_code.py b/pw_presubmit/py/pw_presubmit/format_code.py
index 4f84408..19d0954 100755
--- a/pw_presubmit/py/pw_presubmit/format_code.py
+++ b/pw_presubmit/py/pw_presubmit/format_code.py
@@ -237,6 +237,7 @@
 class CodeFormat(NamedTuple):
     language: str
     extensions: Collection[str]
+    exclude: Collection[str]
     check: Callable[[Iterable], Dict[Path, str]]
     fix: Callable[[Iterable], None]
 
@@ -244,38 +245,39 @@
 C_FORMAT: CodeFormat = CodeFormat(
     'C and C++',
     frozenset(['.h', '.hh', '.hpp', '.c', '.cc', '.cpp', '.inc', '.inl']),
-    clang_format_check, clang_format_fix)
+    (r'\.pb\.h$', r'\.pb\.c$'), clang_format_check, clang_format_fix)
 
-PROTO_FORMAT: CodeFormat = CodeFormat('Protocol buffer', ('.proto', ),
+PROTO_FORMAT: CodeFormat = CodeFormat('Protocol buffer', ('.proto', ), (),
                                       clang_format_check, clang_format_fix)
 
-JAVA_FORMAT: CodeFormat = CodeFormat('Java', ('.java', ), clang_format_check,
-                                     clang_format_fix)
+JAVA_FORMAT: CodeFormat = CodeFormat('Java', ('.java', ), (),
+                                     clang_format_check, clang_format_fix)
 
-JAVASCRIPT_FORMAT: CodeFormat = CodeFormat('JavaScript', ('.js', ),
+JAVASCRIPT_FORMAT: CodeFormat = CodeFormat('JavaScript', ('.js', ), (),
                                            clang_format_check,
                                            clang_format_fix)
 
-GO_FORMAT: CodeFormat = CodeFormat('Go', ('.go', ), check_go_format,
+GO_FORMAT: CodeFormat = CodeFormat('Go', ('.go', ), (), check_go_format,
                                    fix_go_format)
 
-PYTHON_FORMAT: CodeFormat = CodeFormat('Python', ('.py', ), check_py_format,
-                                       fix_py_format)
+PYTHON_FORMAT: CodeFormat = CodeFormat('Python', ('.py', ), (),
+                                       check_py_format, fix_py_format)
 
-GN_FORMAT: CodeFormat = CodeFormat('GN', ('.gn', '.gni'), check_gn_format,
+GN_FORMAT: CodeFormat = CodeFormat('GN', ('.gn', '.gni'), (), check_gn_format,
                                    fix_gn_format)
 
 # TODO(pwbug/191): Add real code formatting support for Bazel and CMake
-BAZEL_FORMAT: CodeFormat = CodeFormat('Bazel', ('BUILD', ),
+BAZEL_FORMAT: CodeFormat = CodeFormat('Bazel', ('BUILD', ), (),
                                       check_trailing_space, fix_trailing_space)
 
 CMAKE_FORMAT: CodeFormat = CodeFormat('CMake', ('CMakeLists.txt', '.cmake'),
-                                      check_trailing_space, fix_trailing_space)
+                                      (), check_trailing_space,
+                                      fix_trailing_space)
 
-RST_FORMAT: CodeFormat = CodeFormat('reStructuredText', ('.rst', ),
+RST_FORMAT: CodeFormat = CodeFormat('reStructuredText', ('.rst', ), (),
                                     check_trailing_space, fix_trailing_space)
 
-MARKDOWN_FORMAT: CodeFormat = CodeFormat('Markdown', ('.md', ),
+MARKDOWN_FORMAT: CodeFormat = CodeFormat('Markdown', ('.md', ), (),
                                          check_trailing_space,
                                          fix_trailing_space)
 
@@ -297,6 +299,7 @@
 def presubmit_check(code_format: CodeFormat, **filter_paths_args) -> Callable:
     """Creates a presubmit check function from a CodeFormat object."""
     filter_paths_args.setdefault('endswith', code_format.extensions)
+    filter_paths_args.setdefault('exclude', code_format.exclude)
 
     @pw_presubmit.filter_paths(**filter_paths_args)
     def check_code_format(ctx: pw_presubmit.PresubmitContext):
diff --git a/pw_presubmit/py/pw_presubmit/pigweed_presubmit.py b/pw_presubmit/py/pw_presubmit/pigweed_presubmit.py
index dbaedf9..eb37b7c 100755
--- a/pw_presubmit/py/pw_presubmit/pigweed_presubmit.py
+++ b/pw_presubmit/py/pw_presubmit/pigweed_presubmit.py
@@ -205,6 +205,8 @@
     r'\bpackage.json$',
     r'\byarn.lock$',
     r'\bpw_web_ui/types/serial.d.ts$',
+    r'\.pb\.h$',
+    r'\.pb\.c$',
 )
 
 
diff --git a/pw_presubmit/py/pw_presubmit/presubmit.py b/pw_presubmit/py/pw_presubmit/presubmit.py
index de12e80..3f7b532 100644
--- a/pw_presubmit/py/pw_presubmit/presubmit.py
+++ b/pw_presubmit/py/pw_presubmit/presubmit.py
@@ -554,7 +554,7 @@
     return filter_paths_for_function
 
 
-@filter_paths(endswith='.h')
+@filter_paths(endswith='.h', exclude=(r'\.pb\.h$', ))
 def pragma_once(ctx: PresubmitContext) -> None:
     """Presubmit check that ensures all header files contain '#pragma once'."""