diff --git a/ChangeLog.d/spm_build.txt b/ChangeLog.d/spm_build.txt
new file mode 100644
index 0000000..6016d84
--- /dev/null
+++ b/ChangeLog.d/spm_build.txt
@@ -0,0 +1,4 @@
+Bugfix
+   * When MBEDTLS_PSA_CRYPTO_SPM is enabled, crypto_spe.h was not included
+     in all the right places. Include it from crypto_platform.h, which is
+     the natural place. Fixes #4649.
diff --git a/include/psa/crypto_platform.h b/include/psa/crypto_platform.h
index d60b773..edf7210 100644
--- a/include/psa/crypto_platform.h
+++ b/include/psa/crypto_platform.h
@@ -82,6 +82,18 @@
 
 #endif /* MBEDTLS_PSA_CRYPTO_KEY_ID_ENCODES_OWNER */
 
+/*
+ * When MBEDTLS_PSA_CRYPTO_SPM is defined, the code is being built for SPM
+ * (Secure Partition Manager) integration which separates the code into two
+ * parts: NSPE (Non-Secure Processing Environment) and SPE (Secure Processing
+ * Environment). When building for the SPE, an additional header file should be
+ * included.
+ */
+#if defined(MBEDTLS_PSA_CRYPTO_SPM)
+#define PSA_CRYPTO_SECURE 1
+#include "crypto_spe.h"
+#endif // MBEDTLS_PSA_CRYPTO_SPM
+
 #if defined(MBEDTLS_PSA_CRYPTO_EXTERNAL_RNG)
 /** The type of the context passed to mbedtls_psa_external_get_random().
  *
diff --git a/library/psa_crypto.c b/library/psa_crypto.c
index 4f932c6..8b102bb 100644
--- a/library/psa_crypto.c
+++ b/library/psa_crypto.c
@@ -26,7 +26,6 @@
 #include "check_crypto_config.h"
 #endif
 
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 
 #include "psa_crypto_cipher.h"
diff --git a/library/psa_crypto_client.c b/library/psa_crypto_client.c
index e84cf30..629feb7 100644
--- a/library/psa_crypto_client.c
+++ b/library/psa_crypto_client.c
@@ -19,7 +19,6 @@
  */
 
 #include "common.h"
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 
 #if defined(MBEDTLS_PSA_CRYPTO_CLIENT)
diff --git a/library/psa_crypto_service_integration.h b/library/psa_crypto_service_integration.h
deleted file mode 100644
index 87889af..0000000
--- a/library/psa_crypto_service_integration.h
+++ /dev/null
@@ -1,39 +0,0 @@
-/*
- *  Copyright The Mbed TLS Contributors
- *  SPDX-License-Identifier: Apache-2.0
- *
- *  Licensed under the Apache License, Version 2.0 (the "License"); you may
- *  not use this file except in compliance with the License.
- *  You may obtain a copy of the License at
- *
- *  http://www.apache.org/licenses/LICENSE-2.0
- *
- *  Unless required by applicable law or agreed to in writing, software
- *  distributed under the License is distributed on an "AS IS" BASIS, WITHOUT
- *  WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
- *  See the License for the specific language governing permissions and
- *  limitations under the License.
- */
-
-#ifndef PSA_CRYPTO_SERVICE_INTEGRATION_H
-#define PSA_CRYPTO_SERVICE_INTEGRATION_H
-
-/*
- * When MBEDTLS_PSA_CRYPTO_SPM is defined, the code is being built for SPM
- * (Secure Partition Manager) integration which separates the code into two
- * parts: NSPE (Non-Secure Processing Environment) and SPE (Secure Processing
- * Environment). When building for the SPE, an additional header file should be
- * included.
- */
-#if defined(MBEDTLS_PSA_CRYPTO_SPM)
-/*
- * PSA_CRYPTO_SECURE means that the file which included this file is being
- * compiled for SPE. The files crypto_structs.h and crypto_types.h have
- * different implementations for NSPE and SPE and are compiled according to this
- * flag.
- */
-#define PSA_CRYPTO_SECURE 1
-#include "crypto_spe.h"
-#endif // MBEDTLS_PSA_CRYPTO_SPM
-
-#endif // PSA_CRYPTO_SERVICE_INTEGRATION_H
diff --git a/library/psa_crypto_slot_management.c b/library/psa_crypto_slot_management.c
index a95b4b3..925d684 100644
--- a/library/psa_crypto_slot_management.c
+++ b/library/psa_crypto_slot_management.c
@@ -22,7 +22,6 @@
 
 #if defined(MBEDTLS_PSA_CRYPTO_C)
 
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 
 #include "psa_crypto_core.h"
diff --git a/library/psa_crypto_storage.c b/library/psa_crypto_storage.c
index 575e992..09cbab4 100644
--- a/library/psa_crypto_storage.c
+++ b/library/psa_crypto_storage.c
@@ -25,7 +25,6 @@
 #include <stdlib.h>
 #include <string.h>
 
-#include "psa_crypto_service_integration.h"
 #include "psa/crypto.h"
 #include "psa_crypto_storage.h"
 #include "mbedtls/platform_util.h"
diff --git a/tests/include/spe/crypto_spe.h b/tests/include/spe/crypto_spe.h
new file mode 100644
index 0000000..f80fd86
--- /dev/null
+++ b/tests/include/spe/crypto_spe.h
@@ -0,0 +1,132 @@
+/*
+ * Copyright (c) 2019-2021, Arm Limited. All rights reserved.
+ *
+ * SPDX-License-Identifier: BSD-3-Clause
+ *
+ */
+
+/**
+ * \file crypto_spe.h
+ *
+ * \brief When Mbed Crypto is built with the MBEDTLS_PSA_CRYPTO_SPM option
+ *        enabled, this header is included by all .c files in Mbed Crypto that
+ *        use PSA Crypto function names. This avoids duplication of symbols
+ *        between TF-M and Mbed Crypto.
+ *
+ * \note  This file should be included before including any PSA Crypto headers
+ *        from Mbed Crypto.
+ */
+
+#ifndef CRYPTO_SPE_H
+#define CRYPTO_SPE_H
+
+#define PSA_FUNCTION_NAME(x) mbedcrypto__ ## x
+
+#define psa_crypto_init \
+        PSA_FUNCTION_NAME(psa_crypto_init)
+#define psa_key_derivation_get_capacity \
+        PSA_FUNCTION_NAME(psa_key_derivation_get_capacity)
+#define psa_key_derivation_set_capacity \
+        PSA_FUNCTION_NAME(psa_key_derivation_set_capacity)
+#define psa_key_derivation_input_bytes \
+        PSA_FUNCTION_NAME(psa_key_derivation_input_bytes)
+#define psa_key_derivation_output_bytes \
+        PSA_FUNCTION_NAME(psa_key_derivation_output_bytes)
+#define psa_key_derivation_input_key \
+        PSA_FUNCTION_NAME(psa_key_derivation_input_key)
+#define psa_key_derivation_output_key \
+        PSA_FUNCTION_NAME(psa_key_derivation_output_key)
+#define psa_key_derivation_setup \
+        PSA_FUNCTION_NAME(psa_key_derivation_setup)
+#define psa_key_derivation_abort \
+        PSA_FUNCTION_NAME(psa_key_derivation_abort)
+#define psa_key_derivation_key_agreement \
+        PSA_FUNCTION_NAME(psa_key_derivation_key_agreement)
+#define psa_raw_key_agreement \
+        PSA_FUNCTION_NAME(psa_raw_key_agreement)
+#define psa_generate_random \
+        PSA_FUNCTION_NAME(psa_generate_random)
+#define psa_aead_encrypt \
+        PSA_FUNCTION_NAME(psa_aead_encrypt)
+#define psa_aead_decrypt \
+        PSA_FUNCTION_NAME(psa_aead_decrypt)
+#define psa_open_key \
+        PSA_FUNCTION_NAME(psa_open_key)
+#define psa_close_key \
+        PSA_FUNCTION_NAME(psa_close_key)
+#define psa_import_key \
+        PSA_FUNCTION_NAME(psa_import_key)
+#define psa_destroy_key \
+        PSA_FUNCTION_NAME(psa_destroy_key)
+#define psa_get_key_attributes \
+        PSA_FUNCTION_NAME(psa_get_key_attributes)
+#define psa_reset_key_attributes \
+        PSA_FUNCTION_NAME(psa_reset_key_attributes)
+#define psa_export_key \
+        PSA_FUNCTION_NAME(psa_export_key)
+#define psa_export_public_key \
+        PSA_FUNCTION_NAME(psa_export_public_key)
+#define psa_purge_key \
+        PSA_FUNCTION_NAME(psa_purge_key)
+#define psa_copy_key \
+        PSA_FUNCTION_NAME(psa_copy_key)
+#define psa_cipher_operation_init \
+        PSA_FUNCTION_NAME(psa_cipher_operation_init)
+#define psa_cipher_generate_iv \
+        PSA_FUNCTION_NAME(psa_cipher_generate_iv)
+#define psa_cipher_set_iv \
+        PSA_FUNCTION_NAME(psa_cipher_set_iv)
+#define psa_cipher_encrypt_setup \
+        PSA_FUNCTION_NAME(psa_cipher_encrypt_setup)
+#define psa_cipher_decrypt_setup \
+        PSA_FUNCTION_NAME(psa_cipher_decrypt_setup)
+#define psa_cipher_update \
+        PSA_FUNCTION_NAME(psa_cipher_update)
+#define psa_cipher_finish \
+        PSA_FUNCTION_NAME(psa_cipher_finish)
+#define psa_cipher_abort \
+        PSA_FUNCTION_NAME(psa_cipher_abort)
+#define psa_hash_operation_init \
+        PSA_FUNCTION_NAME(psa_hash_operation_init)
+#define psa_hash_setup \
+        PSA_FUNCTION_NAME(psa_hash_setup)
+#define psa_hash_update \
+        PSA_FUNCTION_NAME(psa_hash_update)
+#define psa_hash_finish \
+        PSA_FUNCTION_NAME(psa_hash_finish)
+#define psa_hash_verify \
+        PSA_FUNCTION_NAME(psa_hash_verify)
+#define psa_hash_abort \
+        PSA_FUNCTION_NAME(psa_hash_abort)
+#define psa_hash_clone \
+        PSA_FUNCTION_NAME(psa_hash_clone)
+#define psa_hash_compute \
+        PSA_FUNCTION_NAME(psa_hash_compute)
+#define psa_hash_compare \
+        PSA_FUNCTION_NAME(psa_hash_compare)
+#define psa_mac_operation_init \
+        PSA_FUNCTION_NAME(psa_mac_operation_init)
+#define psa_mac_sign_setup \
+        PSA_FUNCTION_NAME(psa_mac_sign_setup)
+#define psa_mac_verify_setup \
+        PSA_FUNCTION_NAME(psa_mac_verify_setup)
+#define psa_mac_update \
+        PSA_FUNCTION_NAME(psa_mac_update)
+#define psa_mac_sign_finish \
+        PSA_FUNCTION_NAME(psa_mac_sign_finish)
+#define psa_mac_verify_finish \
+        PSA_FUNCTION_NAME(psa_mac_verify_finish)
+#define psa_mac_abort \
+        PSA_FUNCTION_NAME(psa_mac_abort)
+#define psa_sign_hash \
+        PSA_FUNCTION_NAME(psa_sign_hash)
+#define psa_verify_hash \
+        PSA_FUNCTION_NAME(psa_verify_hash)
+#define psa_asymmetric_encrypt \
+        PSA_FUNCTION_NAME(psa_asymmetric_encrypt)
+#define psa_asymmetric_decrypt \
+        PSA_FUNCTION_NAME(psa_asymmetric_decrypt)
+#define psa_generate_key \
+        PSA_FUNCTION_NAME(psa_generate_key)
+
+#endif /* CRYPTO_SPE_H */
diff --git a/tests/scripts/all.sh b/tests/scripts/all.sh
index fe53669..596e27d 100755
--- a/tests/scripts/all.sh
+++ b/tests/scripts/all.sh
@@ -820,6 +820,32 @@
     make test
 }
 
+# check_renamed_symbols HEADER LIB
+# Check that if HEADER contains '#define MACRO ...' then MACRO is not a symbol
+# name is LIB.
+check_renamed_symbols () {
+    ! nm "$2" | sed 's/.* //' |
+      grep -x -F "$(sed -n 's/^ *# *define  *\([A-Z_a-z][0-9A-Z_a-z]*\)..*/\1/p' "$1")"
+}
+
+component_build_psa_crypto_spm () {
+    msg "build: full config - USE_PSA_CRYPTO + PSA_CRYPTO_KEY_ID_ENCODES_OWNER + PSA_CRYPTO_SPM, make, gcc"
+    scripts/config.py full
+    scripts/config.py unset MBEDTLS_USE_PSA_CRYPTO
+    scripts/config.py unset MBEDTLS_PSA_CRYPTO_BUILTIN_KEYS
+    scripts/config.py set MBEDTLS_PSA_CRYPTO_KEY_ID_ENCODES_OWNER
+    scripts/config.py set MBEDTLS_PSA_CRYPTO_SPM
+    # We can only compile, not link, since our test and sample programs
+    # aren't equipped for the modified names used when MBEDTLS_PSA_CRYPTO_SPM
+    # is active.
+    make CC=gcc CFLAGS='-Werror -Wall -Wextra -I../tests/include/spe' lib
+
+    # Check that if a symbol is renamed by crypto_spe.h, the non-renamed
+    # version is not present.
+    echo "Checking for renamed symbols in the library"
+    if_build_succeeded check_renamed_symbols tests/include/spe/crypto_spe.h library/libmbedcrypto.a
+}
+
 component_test_psa_crypto_client () {
     msg "build: default config - PSA_CRYPTO_C + PSA_CRYPTO_CLIENT, make"
     scripts/config.py unset MBEDTLS_PSA_CRYPTO_C